Blood Tests to Monitor While Taking Biologics for Autoimmune Diseases

Learn about key blood tests to monitor your health while on biologic therapy for autoimmune diseases.

Oct 1, 2026 3 min read

Biologic therapies have become a vital treatment option for many autoimmune diseases, helping to control symptoms and improve quality of life. However, these powerful medications can also affect your body in various ways, making regular blood tests an important part of your treatment plan. This guide explains the key blood tests to monitor while taking biologics, why they matter, and what to discuss with your healthcare provider.

What are biologics?

Biologics are a type of medication derived from living organisms, used to treat various autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease. They work by targeting specific parts of the immune system to reduce inflammation and prevent damage to your body. While effective, biologics can also suppress the immune system, which is why monitoring through blood tests is crucial.

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Key blood tests to monitor

Complete Blood Count (CBC)

A complete blood count (CBC) measures different components of your blood, including red blood cells, white blood cells, and platelets. Biologics can affect your white blood cell count, which is important for fighting infections. Regular CBC tests can help detect changes that might indicate a risk of infection or other issues.

Liver Function Tests (LFTs)

Liver function tests (LFTs) assess how well your liver is working by measuring levels of liver enzymes and proteins in your blood. Some biologics can affect liver function, so it's important to monitor these levels regularly to ensure your liver is healthy and processing the medication effectively.

Kidney Function Tests

Kidney function tests evaluate how well your kidneys are filtering waste from your blood. Biologics can sometimes affect kidney function, so these tests help ensure your kidneys are working properly and that the medication is not causing harm.

Inflammatory Markers

Tests for inflammatory markers, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), are used to assess the level of inflammation in your body. These markers can help determine how well the biologic is controlling your autoimmune disease and whether adjustments to your treatment are needed.

Why monitoring is important

Monitoring blood tests while on biologics is crucial for several reasons. It helps detect potential side effects early, ensures that the medication is working effectively, and guides any necessary adjustments to your treatment plan. Regular testing can also provide peace of mind, knowing that your health is being closely watched and managed.

Frequently asked questions

What happens if my blood test results are abnormal? If your blood test results are abnormal, your healthcare provider may adjust your medication dosage, switch to a different biologic, or recommend additional tests to investigate further.

How often should I have blood tests while on biologics? The frequency of blood tests varies depending on the specific biologic and your individual health needs. Your healthcare provider will determine the best schedule for you.

Can I take other medications while on biologics? It's important to discuss all medications, supplements, and over-the-counter drugs with your healthcare provider to avoid potential interactions with biologics.

When to see a doctor

While on biologics, contact your healthcare provider if you experience symptoms such as fever, unexplained bruising or bleeding, persistent fatigue, or signs of infection like a sore throat or cough. These could indicate potential side effects or complications that need medical attention.

Remember, this article is for informational purposes only. Always consult your healthcare provider for medical advice and decisions about your treatment.

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