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Blood Tests to Determine the Cause of Fever

Learn which blood tests can help identify the cause of a fever and understand when to consult a doctor.

Jul 22, 2026 3 min read

Experiencing a fever can be concerning, especially when its cause is unknown. Blood tests can be a helpful tool in identifying the underlying reasons for a fever. This article will guide you through the most common blood tests used to determine the cause of a fever, why they matter, and when you should consider consulting a healthcare professional.

What is a Fever and Why is it Important?

A fever is a temporary increase in body temperature, often due to an illness. It is usually a sign that the body is fighting an infection. Normal body temperature typically ranges from 97°F to 99°F (36.1°C to 37.2°C). A fever is generally considered to be a body temperature of 100.4°F (38°C) or higher. While a mild fever may not be cause for concern, persistent or high fevers can indicate a more serious condition that requires medical attention.

Common Blood Tests to Investigate Fever

When a fever persists or its cause is unclear, doctors may order several blood tests to help identify the underlying problem.

  • Complete Blood Count (CBC): This test measures various components of your blood, including white blood cells, which increase in number during infections. A CBC can help determine if your fever is due to a bacterial or viral infection.

  • C-reactive Protein (CRP) Test: CRP is a substance produced by the liver in response to inflammation. High levels of CRP in the blood can indicate an infection or inflammatory condition, helping to pinpoint the cause of a fever.

  • Erythrocyte Sedimentation Rate (ESR): This test measures how quickly red blood cells settle at the bottom of a test tube. A faster-than-normal rate may suggest inflammation in the body, which can be associated with fever.

  • Blood Culture: This test checks for bacteria or fungi in the blood. It is particularly useful if a bloodstream infection is suspected.

  • Liver Function Tests (LFTs): These tests assess the health of your liver and can help identify liver infections or diseases that might cause fever.

Factors that Can Influence Blood Test Results

Several factors can influence the results of these blood tests, including medications, underlying health conditions, and recent illnesses. It's important to inform your healthcare provider of any medications you are taking or recent health changes, as these can affect test outcomes and interpretation.

Frequently Asked Questions

What should I do if blood tests show a high white blood cell count? A high white blood cell count often indicates an infection or inflammation. Your healthcare provider will interpret the results in the context of your symptoms and may recommend further testing or treatment.

Can fever be caused by something other than an infection? Yes, fever can be caused by non-infectious factors such as autoimmune diseases, certain medications, or cancers. Blood tests can help identify these other causes.

How long do blood test results for fever take? The time it takes to receive blood test results can vary. Some tests, like a CBC, may be available within a few hours, while others, such as blood cultures, can take a few days.

When to See a Doctor

You should consider seeing a healthcare professional if you have a fever that lasts longer than a few days, is very high (above 103°F or 39.4°C), or is accompanied by severe symptoms such as difficulty breathing, chest pain, confusion, or persistent vomiting. These could be signs of a more serious condition that requires prompt medical attention.

Remember, this information is for educational purposes only and any decisions about your health should be made in consultation with your healthcare provider.

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