Blood Tests to Investigate the Cause of Chills

Explore which blood tests can help determine the cause of chills and understand when to consult a doctor.

Jul 23, 2026 4 min read

Experiencing chills can be uncomfortable and sometimes concerning. Chills are sensations of coldness accompanied by shivering and can occur with or without a fever. They are often a response to an underlying condition or infection, and blood tests can be a valuable tool in identifying the cause. Understanding which tests may be involved and what they indicate can help you and your healthcare provider determine the best course of action.

What are chills and why do they matter?

Chills are often a sign that your body is trying to fight off an infection, such as the flu or a bacterial infection. They can also be associated with other conditions, including low blood sugar, anxiety, or exposure to cold environments. Recognizing chills as a symptom can help in diagnosing the underlying issue.

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Common causes of chills

Chills can be caused by a variety of factors:

  • Infections: Viral and bacterial infections, such as the flu or pneumonia, are common causes of chills. The body's immune response to fight the infection often leads to chills and fever.
  • Cold exposure: Being in a cold environment or wearing insufficient clothing can cause chills as the body attempts to maintain its core temperature.
  • Hypothyroidism: An underactive thyroid can slow down metabolism, leading to feelings of coldness and chills.
  • Anemia: A condition where there is a deficiency of red blood cells or hemoglobin, anemia can lead to reduced oxygen delivery to the body’s tissues, causing fatigue and chills.
  • Hypoglycemia: Low blood sugar levels can trigger chills, especially in individuals with diabetes.

Blood tests to consider for chills

When experiencing chills, especially if they are recurrent or severe, several blood tests may be recommended to help identify the cause:

  • Complete Blood Count (CBC): This test measures different components of your blood, such as red blood cells, white blood cells, and platelets. An elevated white blood cell count can indicate an infection or inflammation, which might be causing the chills.
  • C-Reactive Protein (CRP): CRP is a substance produced by the liver in response to inflammation. A high CRP level can suggest the presence of inflammation or infection in the body.
  • Erythrocyte Sedimentation Rate (ESR): This test measures how quickly red blood cells settle at the bottom of a test tube. A faster-than-normal rate may indicate inflammation in the body.
  • Blood Cultures: These tests check for the presence of bacteria or fungi in the blood, which can indicate a systemic infection that might be causing the chills.
  • Thyroid Function Tests: Since thyroid disorders can lead to temperature regulation issues, testing for thyroid hormones can help determine if a thyroid problem is contributing to the chills.

How to interpret blood test results

Understanding your blood test results can provide insight into what might be causing your chills:

  • Elevated White Blood Cell Count: This could indicate an infection, as white blood cells increase in response to pathogens.
  • High CRP Levels: Suggests inflammation, which may be due to infection or other inflammatory conditions.
  • Positive Blood Culture: Indicates the presence of bacteria or fungi in the bloodstream, confirming an infection.
  • Abnormal Thyroid Hormone Levels: May suggest a thyroid disorder, which can affect body temperature regulation.

Factors affecting blood test results

Several factors can influence the results of your blood tests:

  • Medications: Some medications can affect cell counts or hormone levels.
  • Diet and Lifestyle: Recent meals or alcohol consumption can impact certain test results.
  • Underlying Health Conditions: Chronic conditions like diabetes or autoimmune diseases can affect test outcomes.

Frequently asked questions

What are the most common causes of chills without fever?
Chills without fever are often caused by anxiety, exposure to cold, or hypothyroidism.

Can dehydration cause chills?
Yes, dehydration can lead to chills as it affects the body's ability to regulate temperature.

Are chills always a sign of infection?
Not always. While infections are a common cause, chills can also result from other conditions like low blood sugar or anemia.

Can stress cause chills?
Yes, stress and anxiety can cause chills as part of the body's "fight or flight" response.

When to see a doctor

If you experience persistent or severe chills, especially if accompanied by other symptoms like fever, fatigue, or unexplained weight loss, it is advisable to consult a healthcare provider. They can help determine the cause and recommend appropriate tests or treatments. Always discuss your symptoms and test results with a healthcare professional to understand what they mean for your health.

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