Chills: Key Blood Markers Worth Checking

Explore key blood markers to check if you're experiencing chills, a common but sometimes concerning symptom.

Sep 20, 2026 3 min read

Experiencing chills can be unsettling, especially when they occur without an obvious cause like cold weather. Chills are often the body's response to an underlying condition or imbalance. Understanding the blood markers that may be associated with chills can help clarify potential causes and guide further investigation.

What are chills and why do they occur?

Chills are sensations of coldness often accompanied by shivering. They can occur when the body is trying to generate heat in response to a drop in temperature or as part of the body's immune response to infection. Chills can also be a symptom of fever, where the body's set temperature increases to fight off pathogens like bacteria or viruses.

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Key blood markers to consider

When experiencing unexplained chills, certain blood markers can provide insights into potential underlying issues:

  • White Blood Cell Count (WBC): This marker measures the number of white blood cells in the blood. An elevated WBC count can indicate an infection or inflammation, which may be causing chills.

  • C-Reactive Protein (CRP): CRP is a protein produced by the liver in response to inflammation. High levels of CRP can suggest the presence of an inflammatory condition or infection.

  • Erythrocyte Sedimentation Rate (ESR): This test measures how quickly red blood cells settle at the bottom of a test tube. A faster-than-normal rate may indicate inflammation in the body.

  • Blood Cultures: These tests check for the presence of bacteria or fungi in the blood, which can cause chills if an infection is present.

Common causes of chills

Chills can result from various conditions, including:

  • Infections: Bacterial or viral infections, such as the flu or pneumonia, often cause chills as the body attempts to fight off the pathogens.

  • Hypoglycemia: Low blood sugar levels can trigger chills, especially in individuals with diabetes.

  • Hypothyroidism: An underactive thyroid can cause a lower body temperature, leading to chills.

  • Anemia: A deficiency in red blood cells can cause feelings of coldness and chills due to reduced oxygen delivery to tissues.

How to read your test results

Interpreting blood test results should always involve a healthcare professional. However, understanding the basic ranges can help you discuss your results more effectively:

  • WBC Count: Normal ranges are typically between 4,000 and 11,000 cells per microliter of blood. Values outside this range may indicate infection or other conditions.

  • CRP Levels: Normal CRP levels are usually below 10 milligrams per liter. Elevated levels suggest inflammation.

  • ESR: Normal ESR values are generally less than 20 millimeters per hour, but this can vary with age and gender.

Frequently asked questions

What should I do if I experience chills without a fever? Chills without a fever can still indicate an underlying issue. Consider monitoring other symptoms and consulting a healthcare provider if they persist.

Can stress cause chills? Yes, stress can trigger chills as the body's fight-or-flight response may cause a temporary increase in heart rate and shivering.

Are chills always a sign of something serious? Not necessarily. Chills can occur due to minor issues like feeling cold or mild infections. However, persistent or severe chills should be evaluated by a healthcare provider.

When to see a doctor

You should consider seeing a doctor if you experience persistent chills, especially if they are accompanied by other symptoms like fever, confusion, or difficulty breathing. It's essential to seek medical advice for a comprehensive evaluation and appropriate treatment.

Remember, this information is intended to inform and should not replace professional medical advice. Always discuss your health concerns with your healthcare provider.

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