What is Infectious Mononucleosis (Glandular Fever)? A Patient's Guide

Infectious mononucleosis, or glandular fever, is a viral infection causing fatigue and sore throat. Understand its symptoms, causes, and when to consult a doctor.

Sep 1, 2026 3 min read

Infectious mononucleosis, commonly known as glandular fever, is a viral infection that often causes symptoms like fatigue, sore throat, and swollen lymph nodes. It is caused by the Epstein-Barr virus (EBV), which is a member of the herpes virus family. While it is most commonly seen in teenagers and young adults, it can affect people of all ages. Understanding this condition can help you manage symptoms and know when to seek medical advice.

What is Infectious Mononucleosis?

Infectious mononucleosis is a contagious illness caused by the Epstein-Barr virus. It is often referred to as the "kissing disease" because it spreads through saliva. You can get it through kissing, sharing drinks or eating utensils, or coming into contact with infected droplets when someone coughs or sneezes. The virus can incubate in the body for four to six weeks before symptoms appear.

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Symptoms of Infectious Mononucleosis

The symptoms of infectious mononucleosis can vary in severity and may include:

These symptoms can last for weeks, and fatigue may persist for several months after other symptoms have resolved.

Diagnosis and Testing

Diagnosing infectious mononucleosis typically involves a physical examination and discussing your symptoms with a healthcare provider. Blood tests can confirm the diagnosis by checking for elevated white blood cell counts and the presence of antibodies against the Epstein-Barr virus. The monospot test is a common screening tool used to detect heterophile antibodies, which are often present during this infection.

Treatment and Management

There is no specific treatment for infectious mononucleosis, as it is a viral infection that usually resolves on its own. Management focuses on relieving symptoms and includes:

  • Resting to help your body recover
  • Drinking plenty of fluids to stay hydrated
  • Taking over-the-counter pain relievers, like ibuprofen or acetaminophen, to reduce fever and relieve sore throat
  • Avoiding strenuous activities and contact sports to prevent spleen injury

Antibiotics are not effective against viral infections, so they are not used to treat mononucleosis.

Frequently Asked Questions

How long does infectious mononucleosis last? Most symptoms last for two to four weeks, but fatigue can sometimes persist for several months.

Can you get infectious mononucleosis more than once? It is rare to get infectious mononucleosis more than once. Once you have been infected, your body typically builds immunity to the virus.

Is infectious mononucleosis contagious? Yes, it is contagious and spreads through saliva. It is important to avoid sharing drinks, food, or personal items with someone who has the infection.

What is the monospot test? The monospot test is a blood test used to detect heterophile antibodies that are typically present during infectious mononucleosis.

Can infectious mononucleosis cause complications? In some cases, complications can occur, such as an enlarged spleen or liver issues. It is important to monitor symptoms and consult a healthcare provider if they worsen.

When to See a Doctor

Consult a healthcare provider if you experience severe symptoms, such as difficulty breathing or swallowing, intense abdominal pain, or if your symptoms do not improve after a few weeks. Additionally, seek medical attention if you suspect complications like an enlarged spleen or liver problems. Remember, it is always best to discuss any concerns with your healthcare provider.

This article provides information, not medical advice. Decisions about your health should be made with your healthcare provider.

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