general

Understanding Loss of Smell: Blood Tests and Their Role

Explore how blood tests can help identify the causes of loss of smell, also known as anosmia, and when to consult a doctor.

Jul 11, 2026 3 min read

What is Anosmia?

Anosmia is the medical term for the loss of the sense of smell. It can be a temporary or permanent condition and can occur for a variety of reasons. While temporary anosmia is often due to nasal congestion from a cold or allergies, persistent loss of smell may indicate an underlying health issue.

Common Causes of Anosmia

Anosmia can result from nasal obstruction, such as a deviated septum or nasal polyps, viral infections, head trauma, or neurological disorders. In some cases, it may be associated with certain diseases, such as Parkinson's disease or Alzheimer's disease.

Blood Tests to Investigate Anosmia

When the cause of anosmia is not immediately clear, blood tests can help identify potential underlying conditions. Here are some common blood tests that may be ordered:

Complete Blood Count (CBC)

A CBC test measures the levels of different cells in your blood, including red blood cells, white blood cells, and platelets. It can help detect infections or conditions like anemia that might contribute to anosmia.

Thyroid Function Tests

Thyroid function tests assess how well your thyroid gland is working by measuring levels of thyroid hormones in your blood. An underactive thyroid (hypothyroidism) can sometimes lead to a loss of smell.

Vitamin and Mineral Levels

Deficiencies in certain vitamins and minerals, such as vitamin B12 or zinc, can affect your sense of smell. Blood tests can determine if you have any deficiencies that could be contributing to anosmia.

Inflammatory Markers

Tests that measure inflammatory markers, like C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR), can help identify underlying inflammatory or autoimmune conditions that might affect your sense of smell.

When to Consult a Doctor

If you experience a sudden loss of smell, especially if it is accompanied by other symptoms like a fever or difficulty breathing, it is important to consult a doctor. Persistent anosmia without an obvious cause, such as a cold, should also be evaluated by a healthcare professional.

Frequently Asked Questions

Can loss of smell be a sign of COVID-19?

Yes, loss of smell is a symptom that has been associated with COVID-19. If you experience a sudden loss of smell, consider getting tested for COVID-19, especially if you have been exposed to the virus or have other symptoms.

Is anosmia always permanent?

No, anosmia is not always permanent. Many cases are temporary and resolve once the underlying cause is treated or clears up on its own.

Can medications cause loss of smell?

Yes, certain medications can lead to a loss of smell as a side effect. If you suspect your medication is affecting your sense of smell, discuss this with your doctor.

Are there any treatments for anosmia?

Treatment for anosmia depends on the underlying cause. Addressing nasal obstructions, treating infections, or correcting nutritional deficiencies can often restore the sense of smell. In some cases, olfactory training, which involves repeated exposure to different smells, may help.

Conclusion

Loss of smell, or anosmia, can have various causes, and blood tests can be a valuable tool in identifying underlying health issues. If you are experiencing a persistent or sudden loss of smell, consult with your healthcare provider to explore potential causes and treatment options.

This article is for informational purposes only and does not substitute professional medical advice. Always consult your healthcare provider for personalized medical guidance.

Read this in another language

Doctor reviews: 0 - pending

This explainer is queued for our doctor panel and hasn't been individually reviewed yet. It's general information, drawn from standard references - always confirm decisions with your own clinician.

Have your own lab results? Upload your report and get a clear, private AI explanation in minutes — free, in English, Russian or Hebrew.
Analyze my results
Want a verified MD opinion on your own report? From $25, 72-hour SLA. Licensed doctors review your file directly.
Browse doctors