Understanding Mouth Ulcers: Causes and Diagnostic Tests

Explore common causes of mouth ulcers and learn about the tests used to diagnose them. Understand when to consult a doctor for persistent symptoms.

Sep 16, 2026 2 min read

Mouth ulcers, also known as canker sores, are small, painful lesions that develop inside the mouth. They can make eating, drinking, and speaking uncomfortable. While they are usually harmless and resolve on their own, understanding their causes and knowing when to seek medical advice can be helpful.

What Are Mouth Ulcers?

Mouth ulcers are open sores that appear on the soft tissues inside your mouth, such as the inner cheeks, gums, tongue, or floor of the mouth. They are typically round or oval with a white or yellow center and a red border. Unlike cold sores, which are caused by the herpes virus and appear on the lips, mouth ulcers are not contagious.

Have your own lab results? Upload your report and get a clear, private AI explanation in minutes - free, in English, Russian or Hebrew.
Analyze my results

Common Causes of Mouth Ulcers

There are several potential causes of mouth ulcers:

  • Injury or Trauma: Biting the inside of your cheek, brushing too hard, or dental work can cause ulcers.
  • Stress and Hormonal Changes: Emotional stress and hormonal fluctuations, such as those during menstruation, can trigger ulcers.
  • Dietary Deficiencies: Lack of vitamins, particularly vitamin B12, folate, and iron, may lead to mouth ulcers.
  • Food Sensitivities: Certain foods like citrus fruits, tomatoes, and spicy foods can irritate the mouth and cause ulcers.
  • Underlying Health Conditions: Conditions such as celiac disease, Crohn's disease, and Behçet's disease can result in recurrent mouth ulcers.

Diagnostic Tests for Mouth Ulcers

While most mouth ulcers do not require medical tests, persistent or severe cases may need further investigation. Doctors may recommend:

  • Blood Tests: To check for nutritional deficiencies or underlying health conditions.
  • Biopsy: A small tissue sample from the ulcer may be taken if the ulcer does not heal or looks unusual.
  • Allergy Tests: To identify any food sensitivities contributing to the ulcers.

Frequently Asked Questions

What is the difference between a mouth ulcer and a cold sore? Mouth ulcers occur inside the mouth and are not contagious, while cold sores appear on the lips and are caused by the herpes virus.

How long do mouth ulcers last? Most mouth ulcers heal within 1 to 2 weeks without treatment.

Can stress cause mouth ulcers? Yes, stress is a common trigger for mouth ulcers.

Are mouth ulcers a sign of cancer? Mouth ulcers are usually benign. However, if an ulcer does not heal after a few weeks, it should be evaluated by a healthcare provider.

Can mouth ulcers be prevented? Avoiding known triggers, maintaining good oral hygiene, and managing stress can help prevent mouth ulcers.

When to See a Doctor

You should consider consulting a doctor if you experience:

  • Mouth ulcers that persist for more than three weeks
  • Ulcers that are unusually large or painful
  • Frequent recurrence of ulcers
  • Signs of infection, such as fever or swollen lymph nodes

Remember, this information is intended for educational purposes only. Always discuss your symptoms and test results with your healthcare provider to make informed decisions about your health.

Read this in another language

Doctor reviews: 0 - pending

This explainer is queued for our doctor panel and hasn't been individually reviewed yet. It's general information, drawn from standard references - always confirm decisions with your own clinician.

Have your own lab results? Upload your report and get a clear, private AI explanation in minutes - free, in English, Russian or Hebrew.
Analyze my results