Peripheral Artery Disease (PAD): Symptoms and Lab Tests

Learn about the symptoms of Peripheral Artery Disease (PAD) and the lab tests used to diagnose it. Understand when to consult a doctor.

Sep 4, 2026 3 min read

Peripheral artery disease (PAD) is a condition where the arteries that supply blood to your limbs become narrowed or blocked. This can lead to a variety of symptoms, particularly in the legs, and can increase the risk of heart attack and stroke. Understanding the symptoms and the lab tests that help diagnose PAD can empower you to take proactive steps in managing your health.

What is Peripheral Artery Disease?

Peripheral artery disease (PAD) occurs when the arteries outside of the heart and brain, most commonly those supplying the legs, become narrowed due to plaque buildup. This plaque is made up of fat, cholesterol, and other substances in the blood. When these arteries are narrowed, blood flow to your limbs is reduced, which can cause symptoms such as pain and cramping.

Have your own lab results? Upload your report and get a clear, private AI explanation in minutes - free, in English, Russian or Hebrew.
Analyze my results

Symptoms of PAD

The most common symptom of PAD is claudication, which is pain or cramping in the legs or buttocks that occurs during physical activity and is relieved by rest. Other symptoms may include:

  • Weak or numb legs
  • Coldness in your lower leg or foot
  • Sores or wounds on your toes, feet, or legs that heal slowly
  • Change in the color of your legs
  • Decreased pulse or weak pulse in your legs or feet

Lab Tests Used in Diagnosing PAD

Several tests can help diagnose PAD. These include:

  • Ankle-Brachial Index (ABI): This is a simple test that compares the blood pressure in your ankle with the blood pressure in your arm. A lower pressure in the ankle suggests PAD.
  • Doppler Ultrasound: This test uses sound waves to measure the blood flow in your arteries and can detect blockages or narrowing.
  • Blood Tests: While not specific to PAD, blood tests can measure cholesterol and blood sugar levels, which are risk factors for PAD.

Risk Factors and Causes

Several factors can increase your risk of developing PAD, including:

  • Smoking
  • Diabetes
  • High blood pressure
  • High cholesterol
  • Age, particularly over 50
  • Family history of cardiovascular disease These factors contribute to the buildup of plaque in the arteries, leading to PAD.

Frequently Asked Questions

What does claudication feel like? Claudication typically feels like a cramp or ache in the legs or buttocks that occurs during physical activity and goes away with rest.

Can PAD affect other parts of the body? Yes, while it most commonly affects the legs, PAD can also impact other arteries in the body, increasing the risk of heart attack and stroke.

Is PAD reversible? Lifestyle changes and medication can help manage PAD and prevent progression, but the condition itself is not reversible. Early detection and management are key.

When to See a Doctor

You should see a doctor if you experience any symptoms that suggest PAD, such as leg pain during exercise, coldness in the lower legs, or sores on your feet that do not heal. Early diagnosis and treatment can improve quality of life and reduce the risk of serious complications.

Decisions about your health should always be made in consultation with your healthcare provider.

Read this in another language

Doctor reviews: 0 - pending

This explainer is queued for our doctor panel and hasn't been individually reviewed yet. It's general information, drawn from standard references - always confirm decisions with your own clinician.

Have your own lab results? Upload your report and get a clear, private AI explanation in minutes - free, in English, Russian or Hebrew.
Analyze my results