Low 17-hydroxyprogesterone (17-OHP): what it means
A 17-hydroxyprogesterone (17-OHP) result below the normal range is considered low. Here is what a reduced 17-hydroxyprogesterone (17-OHP) can point to, and when it is worth discussing with a doctor.
Reference range: ~0.6–6.7 nmol/L (varies with sex, cycle phase and time of day); raised in congenital adrenal hyperplasia and used in the androgen work-up
Understand your full resultWhat a low 17-hydroxyprogesterone (17-OHP) can mean
- Normal — the expected result; makes congenital adrenal hyperplasia unlikely.
- A controlled level on treatment — in someone known to have CAH, shows the treatment dose is appropriate.
When to discuss with a doctor
17-OHP is a targeted test, requested to diagnose or monitor congenital adrenal hyperplasia, or as part of investigating signs of excess androgens — such as early puberty in a child, or irregular periods, acne and excess hair in a woman where the pattern does not fit typical PCOS. A markedly raised level points to CAH and leads to specialist (endocrine) assessment, sometimes with a stimulation test to confirm milder forms; in someone already diagnosed, it helps guide the treatment dose. Because levels vary with time of day, cycle and sex, correct timing and expert interpretation matter. Mediora.AI shows 17-OHP alongside cortisol, ACTH, testosterone and DHEAS so the adrenal and androgen pattern is read together; the diagnosis and treatment belong with your doctor and an endocrinologist.
Conditions this can relate to
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.