Low 5'-nucleotidase: what it means
A 5'-nucleotidase result below the normal range is considered low. Here is what a reduced 5'-nucleotidase can point to, and when it is worth discussing with a doctor.
Reference range: ~2–15 U/L; a liver-specific enzyme used to confirm that a raised alkaline phosphatase is coming from the liver (cholestasis) rather than from bone
Understand your full resultWhat a low 5'-nucleotidase can mean
- Normal — the expected result; and importantly, a normal 5'-nucleotidase with a high ALP points the source toward bone rather than the liver.
- A low value has no clinical significance.
When to discuss with a doctor
5'-nucleotidase is a specialist confirmatory test, not a routine one. Its value appears in a specific situation: when the alkaline phosphatase is raised and it is not clear whether the source is the liver or the bone. A high 5'-nucleotidase confirms a liver or bile-duct (cholestatic) cause and directs the work-up toward the biliary system — often with liver imaging to look for an obstruction. A normal result with a high ALP points instead toward a bone source. It is interpreted alongside the other liver enzymes and GGT. Mediora.AI shows 5'-nucleotidase together with alkaline phosphatase, GGT and bilirubin so the liver-versus-bone question is answered in context; the interpretation and any further tests belong with your doctor.
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.