Low Androstenedione (A4): what it means
A Androstenedione (A4) result below the normal range is considered low. Here is what a reduced Androstenedione (A4) can point to, and when it is worth discussing with a doctor.
Reference range: ~30–200 ng/dL (varies by sex and assay); an androgen precursor made by the ovaries and adrenal glands — used with testosterone and DHEAS to work up androgen excess (e.g. PCOS, adrenal causes)
Understand your full resultWhat a low Androstenedione (A4) can mean
- Adrenal insufficiency — reduced adrenal androgen output.
- After menopause or with ovarian/adrenal suppression — lower androgen production.
- A generally low level is rarely a clinical problem on its own — it is the high values that are investigated.
When to discuss with a doctor
Androstenedione is a specialist test used mainly when investigating androgen excess in women — symptoms such as hirsutism, acne, thinning scalp hair or irregular periods — rather than as a routine hormone. Its value is in helping locate the source of extra androgens: it is read alongside testosterone and free testosterone (the overall androgen burden), DHEAS (which points to the adrenal glands), and 17-hydroxyprogesterone (which flags inherited adrenal enzyme disorders). A high androstenedione supports conditions such as PCOS or congenital adrenal hyperplasia, and a markedly raised level prompts looking for an androgen-producing tumour. Mediora.AI shows androstenedione alongside testosterone, DHEAS and 17-hydroxyprogesterone so the androgen-source pattern reads together; the interpretation belongs with your doctor or endocrinologist.
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.