Lab marker · Low

Low Aspartate Aminotransferase (AST): what it means

A Aspartate Aminotransferase (AST) result below the normal range is considered low. Here is what a reduced Aspartate Aminotransferase (AST) can point to, and when it is worth discussing with a doctor.

Reference range: Approximately 8–40 U/L; lab-specific

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What a low Aspartate Aminotransferase (AST) can mean

  • Vitamin B6 deficiency — AST is pyridoxal-phosphate-dependent.
  • Severe end-stage liver disease — few remaining hepatocytes.
  • Generally not clinically actionable.

When to discuss with a doctor

AST elevation alongside ALT elevation warrants follow-up with the rest of the liver panel and a primary-care visit. Very-high AST without a corresponding ALT rise should prompt a check of CK (muscle injury) and the haemolysis panel. AST >1000 U/L is acute liver injury and needs same-day evaluation.

Conditions this can relate to

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Mediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.