Low Estradiol (E2): what it means
A Estradiol (E2) result below the normal range is considered low. Here is what a reduced Estradiol (E2) can point to, and when it is worth discussing with a doctor.
Reference range: Varies hugely by sex, cycle phase and menopausal status; follicular 20–150, mid-cycle peak 150–750, luteal 30–450, post-menopause <20 pg/mL
Understand your full resultWhat a low Estradiol (E2) can mean
- Menopause / perimenopause — the defining fall; high FSH + low estradiol.
- Primary ovarian insufficiency — menopause before 40.
- Hypothalamic amenorrhoea — low body fat, over-exercise, stress, eating disorder; low FSH/LH too.
- Hyperprolactinaemia — a high prolactin suppresses the axis.
- Turner syndrome / gonadal dysgenesis — congenital.
- GnRH-analogue treatment — deliberate suppression.
When to discuss with a doctor
Estradiol is almost never read alone — it is paired with FSH and LH to locate the problem at the ovary versus the pituitary/hypothalamus. High FSH + low estradiol in a woman over ~45 with irregular cycles confirms the menopausal transition; the same pattern under 40 means primary ovarian insufficiency and warrants gynaecology + endocrinology. Low FSH/LH + low estradiol points upstream to the hypothalamus (weight, stress, prolactin). Mediora.AI reports estradiol against your sex, cycle phase where known, and its companion hormones; the fertility or menopause decision belongs with your gynaecologist.
Conditions this can relate to
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.