Low GAD-65 autoantibodies: what it means
A GAD-65 autoantibodies result below the normal range is considered low. Here is what a reduced GAD-65 autoantibodies can point to, and when it is worth discussing with a doctor.
Reference range: Most labs report <5 IU/mL negative; positive titres support autoimmune diabetes
Understand your full resultWhat a low GAD-65 autoantibodies can mean
- Type 2 diabetes — typical pattern: negative GAD + preserved C-peptide.
- MODY (monogenic diabetes) — negative GAD; genetic testing required.
- Steroid- or drug-induced hyperglycaemia.
When to discuss with a doctor
Order GAD-65 when the diabetes type is unclear — lean adult with new hyperglycaemia, family history of autoimmunity, atypical response to oral agents, or paediatric presentation. A positive result + low C-peptide changes the treatment plan to insulin earlier rather than later, and triggers screening for other autoimmune conditions (thyroid, adrenal). Very high titres (>2000) flag the rare neurological GAD syndromes — refer neurology. Mediora.AI shows GAD-65 alongside C-peptide so the autoimmune-vs-insulin-resistant pattern is visible at a glance; the diabetes-type decision is endocrinology.
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One value is a snapshot. Upload the full test to see every marker explained together.
Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.