High Gastrin: what it means
A Gastrin result above the normal range is considered high. Here is what a raised Gastrin can point to, and when it is worth discussing with a doctor.
Reference range: fasting <100 pg/mL typical; a markedly high fasting gastrin with acidic stomach contents suggests a gastrin-secreting tumour (Zollinger-Ellison syndrome)
Understand your full resultWhat a high Gastrin can mean
- Acid-suppressing medication (proton-pump inhibitors) — the commonest cause of a raised gastrin; harmless and expected.
- Zollinger-Ellison syndrome (gastrinoma) — a very high gastrin with an acidic stomach; the key diagnosis the test looks for.
- Atrophic gastritis — reduced acid production drives gastrin up appropriately.
- H. pylori infection — can raise gastrin.
- Kidney impairment — reduced clearance.
When to discuss with a doctor
A fasting gastrin is a targeted test, not a routine one — it is mostly ordered when severe, multiple or recurrent peptic ulcers, ulcers in unusual places, or ulcers with diarrhoea raise suspicion of a gastrinoma (Zollinger-Ellison syndrome). Because acid-suppressing medicines are by far the commonest reason for a high gastrin, the result must be read in the context of whether such drugs are being taken and how acidic the stomach is; a truly diagnostic result usually needs the medicine stopped under specialist guidance and confirmatory testing. Mediora.AI can surface a markedly raised gastrin from your results and flag the pattern for review, but sorting a harmless medication effect from a rare tumour is a specialist assessment — the interpretation belongs with your doctor.
Conditions this can relate to
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.