Lab marker · High

High Myeloperoxidase (MPO): what it means

A Myeloperoxidase (MPO) result above the normal range is considered high. Here is what a raised Myeloperoxidase (MPO) can point to, and when it is worth discussing with a doctor.

Reference range: reference range assay-dependent; an enzyme from white blood cells that drives oxidative inflammation in the artery wall — a research/adjunct cardiovascular-risk marker

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What a high Myeloperoxidase (MPO) can mean

  • Increased vascular inflammation and oxidative stress — linked to higher cardiovascular risk and more unstable plaque.
  • In chest-pain assessment — associated with a higher risk of adverse cardiac events (an adjunct, not a diagnostic, use).
  • Active infection or inflammation — because MPO comes from white blood cells, non-cardiac inflammation can raise it.

When to discuss with a doctor

Myeloperoxidase is a specialised, adjunct marker of vascular inflammation, not a routine or standalone diagnostic test. In cardiovascular risk assessment it can add information to markers such as hs-CRP and Lp-PLA2 and the standard lipid picture, and it has been studied in the assessment of chest pain — but it does not diagnose or rule out a heart attack, and chest pain always needs urgent clinical evaluation in its own right. Because it also rises with infection and other inflammation, a high level is interpreted alongside the whole picture rather than acted on alone. Mediora.AI shows MPO with the other inflammation and lipid markers so it is read in context; the interpretation and any action belong with your doctor.

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Mediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.