Low Pepsinogen (I and II): what it means
A Pepsinogen (I and II) result below the normal range is considered low. Here is what a reduced Pepsinogen (I and II) can point to, and when it is worth discussing with a doctor.
Reference range: pepsinogen I ~30–130 ng/mL; a low pepsinogen I and a low pepsinogen I/II ratio suggest atrophy of the stomach lining (atrophic gastritis), a risk marker for gastric cancer
Understand your full resultWhat a low Pepsinogen (I and II) can mean
- Atrophic gastritis — a low pepsinogen I and a low I/II ratio suggest the stomach lining has thinned.
- Increased long-term stomach cancer risk — the reason the test is used as a marker.
- Reduced stomach acid — can impair absorption of iron and vitamin B12.
- Autoimmune (pernicious anaemia) or H. pylori-related atrophy — the common underlying causes.
When to discuss with a doctor
Pepsinogen is a risk marker for the state of the stomach lining rather than a routine test. The pattern to note is a low pepsinogen I with a low pepsinogen I/II ratio, which points to atrophic gastritis — a thinning of the stomach lining that reduces acid, can contribute to iron and vitamin B12 deficiency, and over years raises the risk of stomach cancer. A result suggesting atrophy usually leads to further assessment such as endoscopy, testing for H. pylori, and sometimes ongoing surveillance, guided by a doctor. It is always interpreted together with symptoms, H. pylori status and other results, not on its own. Mediora.AI shows pepsinogen alongside B12 and iron markers so the atrophic-gastritis pattern is visible; the interpretation and any follow-up belong with your doctor.
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Upload your test - freeMediora.AI is informational - interpretation, not a diagnosis. A single out-of-range value is common and often benign; always discuss decisions with your doctor.